●薬剤耐性菌の分子疫学と感染制御
●環境感染制御と新規感染予防策の確立
●医療関連感染および職業感染における医療疫学
●自然災害と感染症に関する研究
●臨床感染症
●環境中の薬剤耐性とワンヘルス
●新型コロナウイルスの感染対策

1. 薬剤耐性菌の分子疫学と感染制御

国内およびフィリピンにおける腸内細菌科細菌の薬剤耐性の現状を明らかにするために、基質特異性拡張型-ラクタマーゼ(ESBL)およびAmpC型-ラクタマーゼに関する分子疫学研究を行った。本邦におけるStenotrophomonas maltophiliaの薬剤感受性、Smqnrおよびプラスミド性キノロン耐性遺伝子について研究した。米国ノースカロライナ大学(UNC)で、カルバペネム耐性腸内細菌科細菌(carbapenem-resistant Enterobacteriaceae, CRE）などの薬剤耐性菌のゲノム疫学および感染制御に関する研究を行った。

●Kanamori H, et al. High prevalence of extended-spectrum β-lactamases and qnr determinants in Citrobacter species from Japan: Dissemination of CTX-M-2. J AntimicrobChemother 66: 2255-2262, 2011

●Kanamori H, et al. Molecular characteristics of extended-spectrum β-lactamases and qnr determinants in Enterobacter species from Japan. PLoS ONE 7: e37967, 2012

●Kanamori H, et al. Molecular characteristics of extended-spectrum β-lactamases in clinical isolates of Enterobacteriaceae from the Philippines. ActaTropica 120: 140-145, 2011

●Kanamori H, et al. Prevalence of Smqnr and plasmid-mediated quinolone resistance determinants in clinical isolates of Stenotrophomonasmaltophilia from Japan: novel variants of Smqnr. New Microbes New Infect 7:8-14, 2015

●Kanamori H, et al. Next-Generation Sequencing and Comparative Analysis of Sequential Outbreaks Caused by Multidrug-Resistant Acinetobacter baumannii at a Large Academic Burn Center. Antimicrob Agents Chemother60:1249-1257, 2016

●Kanamori H, et al. A prolonged outbreak of KPC-3-producing Enterobacter cloacae and Klebsiella pneumoniae driven by multiple mechanisms of resistance transmission at a large academic burn center. Antimicrob Agents Chemother61: e01516-16, 2017

●Kanamori H, et al. Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains. Antimicrob Agents Chemother61: e00912-17, 2017



2. 環境感染制御と新規感染予防策の確立

米国ノースカロライナ大学感染症科・感染制御部に留学し、CREなどの多剤耐性菌や病院環境における消毒や滅菌の研究を行った。医療環境と感染制御に関する研究を継続している。

●Kanamori H, et al. Review of fungal outbreaks and infection prevention in healthcare settings during construction and renovation. Clin Infect Dis 61:433-444, 2015

●Kanamori H, et al. Healthcare Outbreaks Associated With a Water Reservoir and Infection Prevention Strategies. Clin Infect Dis62:1423-1435, 2016

●Kanamori H, et al. Patient Room Decontamination against Carbapenem-Resistant Enterobacteriaceae and Methicillin-Resistant Staphylococcus aureus Using a Fixed Cycle-Time Ultraviolet-C Device and Two Different Radiation Designs. Infect Control HospEpidemiol37:994-996, 2016

●Kanamori H, et al. Healthcare-associated Mycobacterium chimaera transmission and infection prevention challenges: Role of heater-cooler units as a water source in cardiac surgery.Clin Infect Dis64:343-346, 2017

●Kanamori H, et al. The role of patient care items as a fomite in healthcare-associated outbreaks and infection prevention. Clin Infect Dis65:1412-1419, 2017.

●Weber DJ, Kanamori H, Rutala WA. 'No touch' technologies for environmental decontamination: focus on ultraviolet devices and hydrogen peroxide systems. CurrOpin Infect Dis29:424-431, 2016

●Anderson DJ, Chen LF, Weber DJ, Moehring RW, Lewis SS, Triplett PF, Blocker M, Becherer P, Schwab JC, Knelson LP, Lokhnygina Y, Rutala WA, Kanamori H, Gergen MF, Sexton DJ; CDC Prevention Epicenters Program. Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study. Lancet389:805-814, 2017

●Rutala WA, Kanamori H, et al. Evaluation of dilute hydrogen peroxide technology for continuous room decontamination of multidrug-resistant organisms. Infect Control Hosp Epidemiol. 2019;40:1438-1439.
●Rutala WA, Kanamori H, et al. Inactivation of Candida auris and Candida albicans by ultraviolet-C. Infect Control Hosp Epidemiol. 2021in press. doi: 10.1017/ice.2021.214.
●Kanamori H, et al. Perioperative Bacterial Contamination From Patients on Contact Precaution in Operating Room Environment. Open Forum Infect Dis. 2020;7(11):ofaa508. doi: 10.1093/ofid/ofaa508.
●Kanamori H, et al. Microbial Assessment of Health Care-Associated Pathogens on Various Environmental Sites in Patient Rooms After Terminal Room Disinfection. Open Forum Infect Dis. 2021;8(2):ofab008. doi: 10.1093/ofid/ofab008.


3. 医療関連感染および職業感染における医療疫学

感染制御学はさまざまな学問領域が融合した学際的研究が重要であるため、UNC公衆衛生大学院でMPH(Master of Public Health)を取得した。UNC大学病院で医療関連感染および安全器材と針刺し・切創、血液・体液曝露のデータを解析し、医療疫学研究を行った。

●Kanamori H, et al. Descriptive analysis of healthcare-associated infections other than bloodstream, respiratory, urinary tract or surgical site, 2001-2011. Infect Control HospEpidemiol 33: 1276-1278, 2012

●Kanamori H, et al. Longitudinal trends in all healthcare-associated infections through comprehensive hospital-wide surveillance and infection control measures over the past 12 years: substantial burden of healthcare-associated infections outside of intensive care units and "other" types of infection. Infect Control HospEpidemiol36:1139-1147, 2015

●Kanamori H, et al. Prevaccination antibody screening and immunization program for healthcare personnel against measles, mumps, rubella, and varicella in a Japanese tertiary care hospital. Tohoku J Exp Med234:111-116, 2014

●Kanamori H, et al. Impact of Safety-Engineered Devices on the Incidence of Occupational Blood and Body Fluid Exposures Among Healthcare Personnel in an Academic Facility, 2000-2014. Infect Control HospEpidemiol37:497-504, 2016


4.自然災害と感染症に関する研究

東日本大震災後に避難所における感染対策活動を実際に行い、自然災害における感染症および感染対策に関する研究を実施した。震災後結核の臨床的特徴および潜在性結核感染症に関する研究を行った。

●Kanamori H, et al. Latent tuberculosis infection in nurses exposed to tuberculous patients cared for in rooms without negative pressure after the 2011 Great East Japan Earthquake. Infect Control HospEpidemiol 33: 204-206, 2012

●Kanamori H, et al. Tuberculosis exposure among evacuees at a shelter after earthquake, Japan, 2011. Emerg Infect Dis 19: 799-801, 2013

●Kanamori H, et al. Lessons learned from a tuberculosis contact investigation associated with a disaster volunteer after the 2011 Great East Japan Earthquake. Am J RespirCrit Care Med 187: 1278-1279, 2013

●Kanamori H, et al. Lessons learned from earthquake-related tuberculosis exposures in a community shelter, Japan, 2011. Am J Infect Control 42:246-248,2014

●Kanamori H, et al. Clinical and molecular epidemiological features of tuberculosis after the 2011 Japan earthquake and tsunami. Int J Tuberc Lung Dis20:505-514, 2016



5. 臨床感染症

感染症診療で経験した貴重な症例について考察した。

●Kanamori H, et al. Chest wall abscess due to Mycobacterium bovis BCG after intravesical BCG therapy. J ClinMicrobiol 50: 533-535, 2012

●Kanamori H, et al. A case of resistance beyond extensively drug-resistant tuberculosis in Japan. EurRespir J 42: 870-872, 2013

●Kanamori H, et al. A case of culture-negative endocarditis due to Streptococcus tigurinus. J Infect Chemother21:138-140, 2015

●Baba H, Kanamori H, et al. Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide. J Infect Chemother. 2020;26(10):1100-1103.

●Baba H, Kanamori H, et al. A case of meningitis due to extensively drug-resistant Pseudomonas aeruginosa imported through medical evacuation: Genomic and environmental investigation. J Travel Med. 2021 [in press].

●Niitsuma-Sugaya I, Kanamori H, et al. Disseminated Gonococcal Infection in a Patient with Paroxysmal Nocturnal Hemoglobinuria Receiving Eculizumab. Lancet Infect Dis. 2021 2021;21(5):741.

6. 薬剤耐性ワンヘルス

世界各国の土壌・河川等の環境からも薬剤耐性因子が検出され、ワンヘルス（人・動物・環境）の観点から環境中の薬剤耐性対策が注目されている。日本における環境中の薬剤耐性の実態調査を充実させ、薬剤耐性ワンヘルスに関する研究を行っている。

●Baba H, Kanamori H. Are reservoirs and transmission routes the same or different between O157 and non-O157 Shiga toxin-producing Escherichia coli? Clin Infect Dis. 2019 Nov 11. pii: ciz1111. doi: 10.1093/cid/ciz1111.

●Kanamori H, et al. Rethinking One Health approach in the challenging era of COVID-19 pandemic and natural disasters. Infect Ecol Epidemiol. 2020;11(1):1852681. doi: 10.1080/20008686.2020.1852681.

●Kanamori H, et al. Chromobacterium haemolyticum Pneumonia Associated with Near-Drowning and River Water, Japan. Emerg Infect Dis. 2020;26(9):2186-2189.

7. 新型コロナウィルスの感染対策

SARS-CoV-2の伝播と環境感染制御に関する研究を行っている。 ●Kanamori H. Rethinking environmental contamination and fomite transmission of SARS-CoV-2 in the healthcare. J Infect. 2020:S0163-4453(20)30575-2.

●Kanamori H. An overview of research on air and environmental contamination with SARS-CoV-2 in healthcare settings. Infect Control Hosp Epidemiol. 2021 [in press].

●Kanamori H, et al. The role of the healthcare surface environment in SARS-CoV-2 transmission and potential control measures. Clin Infect Dis. 2021;72(11):2052-2061.